When the Food and Drug Administration authorized the emergency use of the Pfizer-BioNTech vaccine in youngsters ages 5 to 11 final month, the company famous that the pediatric model can be a bit totally different than the one for adults: a 3rd the scale, with a special buffer for added stability.
The information set off a wave of disinformation on social media concerning the new ingredient: Tris, or tromethamine.
The ingredient, nevertheless, has a time-tested monitor file of security. It is “a commonly used buffer in a variety of other F.D.A.-approved vaccines and other biologics, including products for use in children,” the company mentioned in its assertion announcing the authorization for Pfizer’s pediatric doses.
Such buffers “help maintain a vaccine’s pH (a measure of how acidic or alkaline a solution is) and stability,” in keeping with the F.D.A., which says that the brand new formulation offers vaccine suppliers extra flexibility in storage.
Pfizer’s pediatric dose additionally removes further salt — sodium chloride and potassium chloride — according to Dr. Sandra Fryhofer, the American Medical Association’s liaison to a Centers for Disease Control and Prevention immunization committee. Taken along with the “tris buffer,” she mentioned in an A.M.A. interview, the modifications “make the vaccine product more stable at regular refrigerator temperatures for longer periods of time. The kid version vials can be stored unopened in regular refrigerators for up to 10 weeks.”
The ingredient just isn’t particular to Pfizer’s pediatric Covid vaccine doses. Kit Longley, a Pfizer spokesman, mentioned in an e mail on Saturday that the compound was being utilized in grownup doses as of this month, and that the manufacturing and ingredient record had been in any other case unchanged. Tromethamine can also be utilized in Moderna’s Covid vaccine.